Pseudosickling of Hemoglobin

نویسندگان

  • Samuel Charache
  • Eva Raik
  • David Holtzclaw
  • Patricia J. Hathaway
  • Elizabeth Powell
  • Patricia Fleming
چکیده

Hemoglobin Setif produces pseudosickling of red cells in vitro; the nature of the process and the conditions that “trigger” it are unknown. Studies of red cells. hemolysates. purified hemoglobin solutions, and artificial mixtures of Hb A and Setif suggest that pseudosickling is produced by intracellular crystallization of insoluble hemoglobin. Increased tonicity of the suspending medium accentuates the process, probably by causing a rise in intracellular

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تاریخ انتشار 2005